Université de Bordeaux

Timetable & learning outcomes

The program will integrate, similarly to the summer school organized in 2019, mixed activities with theoretical courses, practical sessions, applied lectures, videos and round table sessions.

Course content will be divided into lectures on methods and instrumentation (incl. latest generation instrumentation and methods) and lectures and applied interactive sessions on case studies (incl. works of art, museum objects and archaeological / palaeontological samples). Practical sessions will include sample preparation; analysis of peptide, lipid and saccharide fingerprints; bottom up / top down proteomics of ancient proteins; screening and quantification of lipids; mass spectrometry imaging; data processing (sequencing, biological origins, etc.); structural analysis of ancient macromolecules (proteins, lipids, sugars), etc. Particular attention will be paid to the current questions of cultural heritage stakeholders and to the challenges ahead.

Tentative program

Wednesday June 16th, 2021


Virtual registration


Opening remarks


Opening lecture - Mass spectrometry applied to cultural heritage: current achievements and future challenges


Virtual coffee break


Lecture - Chemistry and art at the Metropolitan Museum of Art [New York]: natural organic polymer investigations


Lecture - Research at the National Museum of Prehistory [Les Eyzies] and international principles of resource preservation and knowledge development in archaeology




180 second presentations (10 attendees)


Lecture - Sample preparation and minimally invasive methods for proteomics: principles and case studies applied to artworks and archaeological samples


Best practices (videos, on-line practicals)

  • Peptides, proteins 

  • Lipids, sugars, other polymers

  • Sampling and storage


Virtual icebreaker


Thursday June 17th, 2021


Lecture - Palaeoproteomics to unleash the study of human history


Lecture - Proteomics / Palaeoproteomics: workflow, analytical designs


Virtual coffee break


Practicals - methods

  • Bottom up methods: LC MS, ZooMS

  • Top down methods: MALDI-based, LC MS

  • Challenges: deep proteome, screening / automation, questioning the unknown part of datasets, etc.


Summary - general discussion




180 second presentations (10 attendees)


Lecture - Authentication


Lecture - Bioinformatics of ancient proteins


Praticals - applied case studies

  • Authentication

  • Data processing, protein modification / substitution

  • Protein networks, crosslinkings, degradation


Summary - general discussion


Lecture - Ethics


Friday June 18th, 2021


Virtual breakfast


Lecture - MS imaging fundamentals and MSI applied to cultural heritage 


Lecture - Lipid degradations in heritage material using TOF-SIMS and LC-MS/MS


Virtual coffee break


Praticals - applied case studies

  • MS imaging

  • Lipid analysis




Lecture - GC-MS and PyGC-MS applied to the study of organic material -proteins, lipids, polysaccharides- in artworks and archaeological samples


Lecture - Ambient MS and SAWN applied to heritage


Virtual coffee break


Award for the best 180 second presentation


Round table: Contribution of Modern Mass Spectrometry to Major Questions of Cultural Heritage (virtual cheese and wine session)


Virtual escape game


Concluding remarks


Expertise upon completion

The summer school offers a unique opportunity to develop strong knowledge in advanced mass spectrometry within a program which links analytical chemists, physicists, experts in formulation, computational modeling experts, conservators, restorers and archaeologists.

A certificate of participation will be awarded to students upon completion of the course.

Program may be subject to change.